Journal article
Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): A systematic review update and individual participant data meta-analysis protocol
MA Holden, DL Burke, J Runhaar, D Van Der Windt, RD Riley, K Dziedzic, A Legha, AL Evans, JH Abbott, K Baker, J Brown, KL Bennell, D Bossen, L Brosseau, K Chaipinyo, R Christensen, T Cochrane, M De Rooij, M Doherty, HP French Show all
BMJ Open | BMJ PUBLISHING GROUP | Published : 2017
Abstract
Introduction: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical func..
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Grants
Awarded by Oak Foundation
Funding Acknowledgements
This work is supported by a Grant from the Chartered Society of Physiotherapy Charitable Trust (grant no PRF/16/A07), and the National Institute for Health Research (NIHR) School of Primary Care Research (grant no 531). MAH was supported by a National Institute for Health Research (NIHR) School of Primary Care Research Fellowship. DLB is currently supported by a NIHR School of Primary Care Research Fellowship. JR received partial funding from a grant of the Dutch Arthritis Foundation for their center of excellence 'osteoarthritis in primary care'. KB is funded by an Australian National Health and Medical Research Council Fellowship (no 1058440). Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). DvdW is a member of PROGRESS Medical Research Council Prognosis Research Strategy (PROGRESS) Partnership (G0902393/99558). KD is part-funded by a Knowledge Mobilisation Research Fellowship (KMRF-2014-03-002) from the NIHR and the NIHR Collaborations for Leadership in Applied Health Research and Care West Midlands. RSH is supported by an Australian Research Council Future Fellowship (FT130100175). NEF, a NIHR Senior Investigator, is supported through an NIHR Research Professorship (NIHR-RP-011-015). The funders did not influence the study design or the writing of this article.